Brevis descriptio:
CAS number: 472-15-1
Formulae hypotheticae: C30H48O3
hypotheticum pondus: 456.71
Chemical structure
| Basic Information | |
| Product nomen | Acidum betulinicum |
| Gradus | Pharma gradus |
| Aspectus | Alba vel off-alba |
| Assay | 98% |
| Vita fasciae | II annis |
| stipare | 25kg/orum |
| Conditio | Stabulum, at copia frigus. Compatible cum validis agentibus oxidizing, calcium gluconatum, barbiturates, magnesium sulfate, phenytoin, B coetus sodium vitaminum. |
Descriptio
Acidum Betulinicum (472-15-1) est Lupane triterpenoideum naturale ex arbore alba betula (Betula pubescens). Apoptosin inducit in variis lineis cellularum.1 Inducit mitochondrialem permeabilitatem transitus pororum aperturae.2 ?Actus chemosensitizer pro anticancer medicamento curationis in chemorisistant colon cancer cellulis lineis.3 Cellam permeabilem.
Usus
Acidum betulinicum est triterpenoideum pentacyclicum naturale. Acidum Betulinicum ostendit anti-inflammationem et actionem anti-HIV. Acidum Betulinicum selective apoptosin in cellulis tumore inducit, per viam mitochondrialem directe activum apoptosis per mechanismum independens p53- et CD95. Acidum Betulinic etiam exhibet TGR5 agonist activitatem.
Acidum betulinicum (BetA) adhibitum est;
1. effectus suos probare sicut agens contra virum Dengue antiviralem (DENV).
2.sicut steroli regulatory interdum inhibitor-bingentis elementi (SREBP) inhibitor ad reprimendam metabolismum lipidorum et proliferation cellularum cellularum renalis carcinoma (ccRCC) cellularum manifestarum.
3. sicut curatio anti-tumoris proprietates suas experiendi ad viability cellae et mortem cellae apoptoticae in multis myeloma exemplaribus pertentat.
Anticancer Research
Compositum hoc triterpene pentacyclicum e Betula et Zizypho speciebus consecutum est, quae ostendit cytotoxicitatem selectivam contra cellulas melanomas humanas (Shoeb2006). Reactivum oxygeni species generat, MAPK cascades, niatopoisomerase I, vetat angiogenesis, modulans transcriptionalactivatorem pro-activum, modulatur activitatem aminopeptidasi-N, et inde inducitapoptosis in cellulis cancer (Desai et al. 2008; Fulda 2008).
Biologicum Actio
Triterpenoidis naturalis, quae actionem anti-HIV et antitumorem exhibet. Productionem oxygenii species reactiva (ROS) et NF- κ B. inducit activitatem agonistam exhibet TRG5 (EC 50 = 1.04 μ M).
Biochem/physiol Actiones
Acidum betulinicum, triterpennum pentacyclicum, selective inducit apoptosin in cellulis tumore, per viam mitochondrialem directe activum apoptosis per mechanismum p53 et CD95-independentem.
